Cholesterol stimulates the cellular uptake of L-carnitine by the carnitine/organic cation transporter novel 2 (OCTN2)
Lu Zhang, Ting Gui, Lara Console, Mariafrancesca Scalise, Cesare Indiveri, Stéphanie Häusler, Gerd A. Kullak‐Ublick, Zhibo Gai, Michele Visentin
Abstract
and, in turn, the L-carnitine maximal transport capacity. Because of the antilipogenic and antioxidant features of L-carnitine, the stimulatory effect of cholesterol on L-carnitine uptake might represent a novel protective effect against lipid-induced toxicity and oxidative stress.
Topics & Concepts
CarnitineOrganic cation transport proteinsTransporterChemistryBiochemistryCholesterolGeneMetabolism and Genetic DisordersAmino Acid Enzymes and MetabolismMitochondrial Function and Pathology