Population Pharmacokinetic and Pharmacodynamic Target Attainment Analysis of Cefazolin in the Serum and Hip Joint Capsule of Patients Undergoing Total Hip Arthroplasty
Toshiaki Komatsu, Yui Natsume, Katsufumi Uchiyama, Shinsuke Ikeda, Y Tomoda, Yoko Takayama, Masashi Takaso, Hideaki Hanaki, Koichiro Atsuda
Abstract
The objectives of this study were to evaluate the population pharmacokinetics of prophylactic cefazolin (CFZ) from its serum and hip joint capsule concentrations in patients undergoing total hip arthroplasty and to establish the pharmacodynamic target concentration exceeding the MIC for designing an effective dosing regimen for serum and the hip joint capsule. We analyzed 249 serum samples and 125 hip joint capsule samples from 125 individuals using a nonlinear mixed-effects model.
Topics & Concepts
CefazolinPharmacodynamicsMedicinePharmacokineticsTotal hip arthroplastyJoint capsuleCapsulePopulationDosingAnesthesiaSurgeryInternal medicineAntibioticsBiologyEnvironmental healthBotanyMicrobiologyAntibiotics Pharmacokinetics and EfficacyOrthopedic Infections and TreatmentsAnesthesia and Pain Management