Fine particulate matter (PM<sub>2.5</sub>) inhalation-induced alterations in the plasma lipidome as promoters of vascular inflammation and insulin resistance
Bradford G. Hill, Benjamin Rood, Amanda Ribble, Petra Haberzettl
Abstract
We found that circulating plasma constituents are responsible for air pollution-induced vascular pathologies. Inhalation of fine particulate matter (≤PM 2.5 ) promotes a unique form of dyslipidemia that manifests in a manner dependent upon pulmonary oxidative stress. The air pollution-engendered dyslipidemic phenotype is characterized by elevated free fatty acid species and diminished phospholipid species, which could contribute to vascular inflammation and loss of insulin sensitivity.
Topics & Concepts
LipidomeInsulin resistanceInflammationParticulatesDyslipidemiaOxidative stressInhalationChemistryEndocrinologyInternal medicineInsulinMedicineDiabetes mellitusLipid metabolismAnatomyOrganic chemistryAir Quality and Health ImpactsAtmospheric chemistry and aerosolsClimate Change and Health Impacts