Toluene Inhalation Causes Early Anxiety and Delayed Depression with Regulation of Dopamine Turnover, 5-HT<sub>1A</sub>Receptor, and Adult Neurogenesis in Mice
Jinhee Kim, Juhee Lim, Seong‐Hee Moon, Kwang‐Hyeon Liu, Hyun Jin Choi
Abstract
) receptor in the hippocampus and the substantia nigra, as well as reduced immunoreactivity of neurogenesis markers in the dentate gyrus, was observed in the mice after two weeks. These results suggest that toluene inhalation, even single exposure, mimics early anxietyand delayed depression-like emotional disturbances, underpinned by pathological changes in the brain.
Topics & Concepts
NeurochemicalDentate gyrusInhalationDopamineSubstantia nigraInternal medicineEndocrinologyHippocampusNeurogenesisPsychologyMedicineChemistryAnesthesiaNeuroscienceDopaminergicNeurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsStress Responses and Cortisol