Human neuromuscular junction on micro-structured microfluidic devices implemented with a custom micro electrode array (MEA)
Pauline Duc, Michel Vignes, Gérald Hugon, Audrey Sebban, Gilles Carnac, Eugene Malyshev, Benoît Charlot, Florence Rage
Abstract
hNMJ modelling. We demonstrate that electrical activation of MNs can trigger recordable extracellular muscle action potentials. This study provides evidence for a physiologically relevant model to mimic a hNMJ that will in the future be a powerful tool, more sensitive than calcium imaging, to better understand and characterize NMJs and their disruption in neurodegenerative diseases.
Topics & Concepts
MicrofluidicsMicroelectrodeMultielectrode arrayElectrode arrayNeuromuscular junctionNeuroscienceMaterials scienceSynapseNanotechnologyElectrodeBiologyChemistryPhysical chemistryNeuroscience and Neural EngineeringMuscle activation and electromyography studiesAdvanced Sensor and Energy Harvesting Materials