Au(I) Catalyzed HF Transfer: Tandem Alkyne Hydrofluorination and Perfluoroarene Functionalization
Daniel Mulryan, Jack Rodwell, Nicholas A. Phillips, Mark R. Crimmin
Abstract
Ar step is turnover-limiting for phenol-based nucleophiles, while protodeuaration likely becomes turnover-limiting for aniline-based nucleophiles. The approach removes the need for direct handling of HF reagents in hydrofluorination and offers possibilities to manipulate the fluorine content of organic molecules through catalysis.
Topics & Concepts
NucleophileChemistryCatalysisAlkyneCombinatorial chemistryAnilineOrganic synthesisReagentPhotochemistryOrganic chemistryFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsCyclopropane Reaction Mechanisms