A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells
Xuguang Zhang, Aixia Liu, Yuxin Zhang, Mingyan Zhou, Xiangyi Li, Minghai Fu, Yipeng Pan, Jian Xu, Junqing Zhang
Topics & Concepts
Insulin receptorProtein kinase BInsulin resistanceIRS1Glucose transporterInsulin receptor substrateSuperoxide dismutasePI3K/AKT/mTOR pathwayInsulinGlucose uptakeBiochemistryBiologyChemistryPharmacologyOxidative stressEndocrinologySignal transductionGinger and Zingiberaceae researchNatural Antidiabetic Agents StudiesCurcumin's Biomedical Applications