Copper-Catalyzed Remote C(sp<sup>3</sup>)–H Amination of Carboxamides
Qingqiang Min, Jiawen Yang, Meng-Juan Pang, Gui‐Zhen Ao, Feng Liu
Abstract
)-H amination of carboxamides by merging transition-metal catalysis and the hydrogen atom transfer strategy. The reaction proceeds through a sequence of favorable single-electron transfer, 1,5-hydrogen atom transfer, and C-N cross-coupling steps, thus allowing access to a series of desired products. This reaction could accommodate a wide diversity of nitrogen nucleophiles as well as demonstrate excellent chemoselectivity and functional group compatibility.
Topics & Concepts
ChemistryAminationCatalysisCopperCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis