CLN7 is an organellar chloride channel regulating lysosomal function
Yayu Wang, Wenping Zeng, Bingqian Lin, Yichuan Yao, Canjun Li, Wenqi Hu, Haotian Wu, Jiamin Huang, Mei Zhang, Tian Xue, Dejian Ren, Lili Qu, Chunlei Cang
Abstract
The disease-associated protein CLN7 forms an organellar chloride channel and regulates lysosomal calcium signaling and function.
Topics & Concepts
Chloride channelTransient receptor potential channelLysosomeLipofuscinCell biologyEndosomeChemistryChlorideBiochemistryBiologyReceptorEnzymeOrganic chemistryCalcium signaling and nucleotide metabolismLysosomal Storage Disorders ResearchCellular transport and secretion