Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease
Per Ludvik Brattås, Bob A. Hersbach, Sofia Madsen, Rebecca Petri, Johan Jakobsson, Karolina Pircs
Abstract
: AAV: adeno-associated viral vectors; ACTB: actin beta; BECN1: beclin 1, autophagy related; DAPI: 4',6-diamidino-2-phenylindole; GO: gene ontology; HD: Huntington disease; HTT: huntingtin; ICQ: Li's intensity correlation quotient; IHC: immunohistochemistry; LAMP1: lysosomal-associated membrane protein 1; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; mHTT: mutant huntingtin; PCA: principal component analysis; PPP1R1B/DARPP-32: protein phosphatase 1 regulatory inhibitor subunit 1B; SQSTM1: sequestosome 1; TFEB: transcription factor EB; WB: western blot; WT: wild-type.
Topics & Concepts
BECN1AutophagyHuntingtinBiologySequestosome 1BAG3Cell biologyHuntington's diseaseProtein aggregationMutantGeneticsGeneDiseaseMedicinePathologyApoptosisGenetic Neurodegenerative DiseasesAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and Disease