Treatment with the senolytics dasatinib/quercetin reduces <scp>SARS‐CoV</scp>‐2‐related mortality in mice
Andrés Pastor Fernández, Antonio Rodríguez Bertos, Arantzazu Sierra‐Ramírez, Javier del Moral‐Salmoral, Javier Merino, Ana Isabel de Ávila, Cristina Olagüe, Ricardo Villares, Gloria González‐Aseguinolaza, María Ángeles Rodríguez, Manuel Fresno, Núria Gironès, Matilde Bustos, Cristian Smerdou, Pablo J. Fernández-Marcos, Cayetano von Kobbe
Abstract
The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the pro-inflammatory immune response against SARS-CoV-2. Therefore, the selective clearance of senescent cells by senolytic drugs may be useful as a therapy to ameliorate the symptoms of COVID-19 in some cases. Using the established COVID-19 murine model K18-hACE2, we demonstrated that a combination of the senolytics dasatinib and quercetin (D/Q) significantly reduced SARS-CoV-2-related mortality, delayed its onset, and reduced the number of other clinical symptoms. The increase in senescent markers that we detected in the lungs in response to SARS-CoV-2 may be related to the post-COVID-19 sequelae described to date. These results place senescent cells as central targets for the treatment of COVID-19, and make D/Q a new and promising therapeutic tool.