Synthesis of benzimidazole by mortar–pestle grinding method
Peng Zhang, Caiqin Liu, Ling Yu, Huiqing Hou, Wei‐Ming Sun, Fang Ke
Abstract
An environmentally friendly and efficient protocol for the synthesis of benzimidazoles by mortar–pestle grinding technique in the presence of acetic acid as a catalyst is reported. This mechanochemical method proceeded with the condensation of aldehyde and o-phenylenediamine followed by cyclization reaction, leading to the formation of the corresponding benzimidazoles in yields up to 97%. This protocol could also be applied for the synthesis of benzothiazoles and benzoxazoles.
Topics & Concepts
ChemistryGrindingMortarBenzimidazoleEnvironmentally friendlyAldehydeAcetic acidCondensationCatalysisCondensation reactionOrganic chemistryChemical engineeringMetallurgyComposite materialMaterials scienceEcologyBiologyThermodynamicsPhysicsEngineeringPhenothiazines and Benzothiazines Synthesis and ActivitiesQuinazolinone synthesis and applicationsSynthesis and biological activity