Intermittent fasting increases fat oxidation and promotes metabolic flexibility in lean mice but not obese type 2 diabetic mice
Meghan O. Conn, Daniel M. Marko, Jonathan D. Schertzer
Abstract
We show that a 5:2 intermittent fasting regimen can increase lipid oxidation without altering body mass in lean mice. Therefore, repeated intermittent fasting can increase metabolic flexibility without the need for (or prior to) weight loss. Intermittent fasting did not increase lipid oxidation in mice with obesity and type 2 diabetes, highlighting that obesity and/or type 2 diabetes limit changes in metabolic flexibility and mitigate increased fatty acid oxidation without weight loss during intermittent fasting.
Topics & Concepts
EndocrinologyInternal medicineBeta oxidationFatty acidAdipocyteType 2 diabetesAdipose tissueFatty acid metabolismCarbohydrate metabolismChemistryObesityMetabolismLipid oxidationLipid metabolismBiologyDiabetes mellitusMedicineBiochemistryAntioxidantDietary Effects on HealthAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases