Ferroptosis: machinery and regulation
Xin Chen, Jingbo Li, Rui Kang, Daniel J. Klionsky, Daolin Tang
Abstract
2ME: beta-mercaptoethanol; α-KG: α-ketoglutarate; ccRCC: clear cell renal cell carcinoma; EMT: epithelial-mesenchymal transition; FAO: fatty acid beta-oxidation; GSH: glutathione; MEFs: mouse embryonic fibroblasts; MUFAs: monounsaturated fatty acids; NO: nitric oxide; NOX: NADPH oxidase; PPP: pentose phosphate pathway; PUFA: polyunsaturated fatty acid; RCD: regulated cell death; RNS: reactive nitrogen species; ROS: reactive oxygen species; RTAs: radical-trapping antioxidants; UPS: ubiquitin-proteasome system; UTR: untranslated region.
Topics & Concepts
BiologyGPX4BiochemistryCell biologyReactive oxygen speciesLipid peroxidationProgrammed cell deathPentose phosphate pathwayGlutathioneOxidative stressApoptosisMetabolismEnzymeGlutathione peroxidaseGlycolysisFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer