Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression
Kumi Mesaki, S. Juvet, Jonathan Yeung, Zehong Guan, Gavin W. Wilson, Jim Hu, Alan R. Davidson, Benjamin P. Kleinstiver, Marcelo Cypel, Mingyao Liu, Shaf Keshavjee
Topics & Concepts
CRISPRDownregulation and upregulationLungIn vivoImmunologyImmunosuppressionTransplantationEx vivoBiologyCancer researchLung transplantationCytokineMedicineGeneInternal medicineGeneticsCRISPR and Genetic EngineeringTransplantation: Methods and OutcomesRenal Transplantation Outcomes and Treatments