The Drug-Drug Interaction between Erlotinib and OSI-930 Is Mediated through Aldehyde Oxidase Inhibition
Lloyd Wei Tat Tang, Yuanyuan Shi, Raman Sharma, R. Scott Obach
Topics & Concepts
ErlotinibMetaboliteAldehyde oxidaseIn vivoDrugChemistryPharmacologyDrug metabolismDrug interactionBiochemistryEpidermal growth factor receptorEnzymeReceptorBiologyXanthine oxidaseGeneticsPharmacogenetics and Drug MetabolismPI3K/AKT/mTOR signaling in cancerPharmacological Effects of Natural Compounds