Unlocking <scp>G‐Quadruplexes</scp> as Targets and Tools against <scp>COVID</scp>‐19
Geng Qin, Chuanqi Zhao, Jie Yang, Zhao Wang, Jinsong Ren, Xiaogang Qu
Abstract
The applicability of G-quadruplexes (G4s) as antiviral targets, therapeutic agents and diagnostic tools for coronavirus disease 2019 (COVID-19) is currently being evaluated, which has drawn the extensive attention of the scientific community. During the COVID-19 pandemic, research in this field is rapidly accumulating. In this review, we summarize the latest achievements and breakthroughs in the use of G4s as antiviral targets, therapeutic agents and diagnostic tools for COVID-19, particularly using G4 ligands. Finally, strength and weakness regarding G4s in anti-SARS-CoV-2 field are highlighted for prospective future projects.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)ChemistrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakG-quadruplexComputational biologyPandemicVirologyDiseaseBiochemistryInfectious disease (medical specialty)BiologyMedicineDNAPathologyOutbreakDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery