New tactics in the design of theranostic radiotracers
Cesare Berton, Simon Klingler, Stanislav Prytuliak, Jason P. Holland
Abstract
In the context of molecularly targeted radiotherapy, dosimetry concerns in off-target tissues are a major limitation to the more wide-spread application of radiopharmaceuticals to treat diseases like cancer. Reducing off-target accumulation of radionuclides in background tissues, whilst maintaining high and specific uptake in disease sites and improving the therapeutic window, requires rethinking common radiotracer design concepts. This article explores ways in which innovative radiotracer chemistry (the making and breaking of bonds) is used to modify interactions with the host organism to control excretion profiles and dosimetry at the tissue-specific level.
Topics & Concepts
Context (archaeology)Therapeutic windowDosimetryRadiochemistryMedical physicsChemistryComputer scienceBiochemical engineeringMedicineNuclear medicinePharmacologyBiologyEngineeringPaleontologyRadiopharmaceutical Chemistry and ApplicationsMass Spectrometry Techniques and ApplicationsMedical Imaging Techniques and Applications