<i>Myo</i>-inositol oxygenase overexpression exacerbates cadmium-induced kidney injury via oxidant stress and necroptosis
Xiaoping Zheng, Fei Deng, Isha Sharma, Yashpal S. Kanwar
Abstract
-inositol oxygenase (MIOX), a renal proximal tubule-specific enzyme, in the exacerbation of cadmium-induced acute kidney injury by perturbing redox balance and inducing necroptosis. MIOX gene disruption or administration of necrostatin-1 (a necroptosis inhibitor) diminished cadmium-induced renal damage, in both in vitro and in vivo systems, suggesting a therapeutic potential of MIOX to attenuate necroptosis and relevant signaling pathways in cadmium-induced renal injury.
Topics & Concepts
NecroptosisOxidative stressProgrammed cell deathKidneyCell biologyHeme oxygenaseBiologyChemistryCancer researchEnzymeBiochemistryApoptosisEndocrinologyHemeHeavy Metal Exposure and ToxicityTrace Elements in Health