Platelet-derived microparticles stimulated by anti-β <sub>2</sub> GPI/β <sub>2</sub> GPI complexes induce pyroptosis of endothelial cells in antiphospholipid syndrome
Longjiang Di, Caijun Zha, Yanhong Liu
Abstract
GPI complexes play a vital role in endothelial cell pyroptosis, and these studies provide major insights into the mechanisms of thrombosis during the treatment of antiphospholipid antibody syndrome.
Topics & Concepts
Antiphospholipid syndromePyroptosisEndothelial stem cellImmunologyPlateletTissue factorPlatelet activationCancer researchAntibodyBiologyCell biologyMedicineInflammationInflammasomeInternal medicineIn vitroBiochemistryCoagulationInflammasome and immune disordersSystemic Lupus Erythematosus ResearchErythrocyte Function and Pathophysiology