Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity
Lisa R. Volpatti, Rachel P. Wallace, Shijie Cao, Michal M. Raczy, Ruyi Wang, Laura Gray, Aaron T. Alpar, Priscilla S. Briquez, Nikolaos Mitrousis, Tiffany M. Marchell, Maria Stella Sasso, Mindy Nguyen, Aslan Mansurov, Erica Budina, Ani Solanki, Elyse A. Watkins, Mathew R. Schnorenberg, Andrew C. Tremain, Joseph W. Reda, Vlad Nicolaescu, Kevin Furlong, Steve Dvorkin, Shann S. Yu, Balaji Manicassamy, James L. LaBelle, Matthew Tirrell, Glenn Randall, Marcin Kwissa, Melody A. Swartz, Jeffrey A. Hubbell
Abstract
T cell responses that produced multiple Th1-type cytokines. We conclude that a multivalent surface display of spike RBD on polymersomes promotes a potent neutralizing antibody response to SARS-CoV-2, while both antigen formulations promote robust T cell immunity.