TMBIM6-mediated miR-181a expression regulates breast cancer cell migration and invasion via the MAPK/ERK signaling pathway
Yeokyung Shin, Hye Yeon Choi, Yeonjoo Kwak, Gwang‐Mo Yang, Yeojin Jeong, Tak-Il Jeon, Jaekwon Seok, Eung-Ryoung Lee, Jung‐Hyun Kim, Kilsoo Jeon, Ahmed Abdal Dayem, Kyung Min Lim, Ssang‐Goo Cho
Abstract
significantly increased cell invasion and migration through up-regulation of mesenchymal markers and matrix metalloproteinase-9 (MMP-9) and enhanced activation of the MAPK/ERK signaling pathway. We also observed that up-regulation of TMBIM6 significantly increased the expression of miR-181a by TMBIM6-mediated pathway. TMBIM6 and miR-181a-mediated ERK activation induced the expression of Snail-1 and Snail-2 in FOSL-1/C-JUN-dependent manner. Overall, our data demonstrated that TMBIM6-induced miR-181a up-regulation plays an important role in the efficient modulation of migration and invasion of breast cancer cells.