Discovery of novel co-degradation CK1α and CDK7/9 PROTACs with p53 activation for treating acute myeloid leukemia
Kai Wang, Meixu Jiang, Huimin Liu, Meng Chen, Mengyuan Li, Haibin Lu
Topics & Concepts
ChemistryMyeloid leukemiaWestern blotCancer researchCytokineCyclin-dependent kinase 7PharmacologyApoptosisImmunologyBiochemistryGeneBiologyProtein kinase BMAP kinase kinase kinaseProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors Research