Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy
Xingang Liu, Min Wu, Meng Wang, Yukun Duan, Chi Uyen Phan, Guobin Qi, Guping Tang, Bin Liu
Abstract
A living therapeutic system based on attenuated Salmonella was developed via metabolic engineering using an aggregation-induced emission (AIE) photosensitizer MA. The engineered bacteria could localize in the tumor tissues and continue to colonize and express exogenous genes. Under light irradiation, the encoded VEGFR2 gene was released and expressed in tumor tissues, which can suppress angiogenesis induced by a T cell-mediated autoimmune response and inhibit tumor growth.
Topics & Concepts
PhotosensitizerSalmonellaPhotodynamic therapyBacteriaAngiogenesisCancer researchChemistryNanotechnologyMedicineBiologyMaterials scienceGeneticsPhotochemistryOrganic chemistryCancer Research and TreatmentsNanoplatforms for cancer theranostics3D Printing in Biomedical Research