Progress and perspectives on directing group-assisted palladium-catalysed C–H functionalisation of amino acids and peptides
Sadegh Shabani, Yuezhou Wu, Hannah G. Ryan, Craig A. Hutton
Abstract
)-H bond functionalisation reactions of amino acids for the formation of C-X bonds with the aid of directing groups and their application in late-stage macrocyclisation and the total synthesis of complex peptide natural products.
Topics & Concepts
Amino acidChemistryPeptideDenticityCombinatorial chemistryPeptide synthesisOrganic synthesisStereochemistryPalladiumPeptide bondCatalysisOrganic chemistryBiochemistryCrystal structureCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsChemical Synthesis and Analysis