Ultrasound-augmented anti-inflammatory exosomes for targeted therapy in rheumatoid arthritis
Yuanjiao Tang, Zihe Wu, Ruiqian Guo, Jianbo Huang, Xiao Rong, Bihui Zhu, Liyun Wang, Lang Ma, Chong Cheng, Li Qiu
Abstract
integrating RAW264.7 macrophage-derived exosomes and a powerful anti-inflammatory immune modulator interleukin-10 by an electroporation method. Then, non-invasive ultrasound was used to increase the permeability of blood vessels and augment the targeted accumulation of AI-Exo to inflammatory tissues, which could promote macrophage polarization to M2 phenotypes, relieve inflammation symptoms, stimulate resolution, and accelerate tissue repair against collagen-induced arthritis. This work intensely supports that ultrasound-augmented AI-Exo has significant targeted anti-inflammatory therapeutic effects, and the combined mechanism of anti-inflammation and pro-resolution gives unique insights into the treatment of not only RA but also other inflammatory diseases, which provides an effective strategy and a promising prospect for future wider biomedical applications and clinical transformations.