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Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

Shihao Xu, Omkar Chaudhary, Patricia Rodríguez-Morales, Xiaoli Sun, Dan Chen, Roberta Zappasodi, Ziyan Xu, Antônio F. M. Pinto, April E. Williams, Isabell Schulze, Yagmur Farsakoglu, Siva Karthik Varanasi, Jun Siong Low, Wenxi Tang, Haiping Wang, Bryan McDonald, Victoria Tripple, Michael Downes, Ronald M. Evans, Nada A. Abumrad, Taha Merghoub, Jedd D. Wolchok, Maxim N. Shokhirev, Ping‐Chih Ho, Joseph L. Witztum, Brinda Emu, Guoliang Cui, Susan M. Kaech

2021Immunity756 citationsDOIOpen Access PDF

Topics & Concepts

CD36Scavenger receptorCD8Lipid peroxidationBiologyTumor microenvironmentT cellCytotoxic T cellImmune systemCell biologyCancer researchChemistryBiochemistryReceptorImmunologyIn vitroAntioxidantLipoproteinCholesterolImmune cells in cancerImmune Cell Function and InteractionChemokine receptors and signaling
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors | Litcius