The <i>parkin-coregulated gene</i> product PACRG promotes TNF signaling by stabilizing LUBAC
Jens Meschede, Maria Šadič, Nikolas Furthmann, Tim Miedema, Dominik A. Sehr, Anne Kathrin Müller-Rischart, Verian Bader, Lena A. Berlemann, Anna Pilsl, Anita Schlierf, Katalin Barkovits, Barbara Kachholz, Katrin Rittinger, Fumiyo Ikeda, Katrin Marcus, Liliana Schaefer, Jörg Tatzelt, Konstanze F. Winklhofer
Abstract
PACRG can functionally substitute for the LUBAC adaptor subunit SHARPIN to stimulate NF-κB signaling.
Topics & Concepts
ParkinBiologySignal transducing adaptor proteinCell biologySignal transductionProtein subunitTumor necrosis factor alphaUbiquitinGeneGeneticsImmunologyMedicineInternal medicineDiseaseParkinson's diseaseUbiquitin and proteasome pathwaysHippo pathway signaling and YAP/TAZCancer-related Molecular Pathways