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Photoinduced Dehydrogenative Borylation via Dihydrogen Bond Bridged Electron Donor and Acceptor Complexes**

Zhiyong Wang, Jiaxin Chen, Zhenyang Lin, Yangjian Quan

2022Chemistry - A European Journal24 citationsDOI

Abstract

Air-stable amine- and phosphine-boranes are discovered as donors to integrate with pyridinium acceptor for generating photoactive electron-donor-acceptor (EDA) complexes. Experimental results and DFT calculations suggest a dihydrogen bond bridging the donor and acceptor. Irradiating the EDA complex enables an intra-complex single electron transfer to give a boron-centered radical for dehydrogenative borylation with no need of external photosensitizer and radical initiator. The deprotonation of Wheland-like radical intermediate rather than its generation is believed to determine the good ortho-selectivity based on DFT calculations. A variety of α-borylated pyridine derivatives have been readily synthesized with good functional group tolerance.

Topics & Concepts

ChemistryBorylationPhotochemistryDeprotonationAcceptorPhotoinduced electron transferPyridiniumPyridineElectron donorElectron transferMedicinal chemistryOrganic chemistryCatalysisArylCondensed matter physicsAlkylPhysicsIonRadical Photochemical ReactionsOrganoboron and organosilicon chemistryCatalytic C–H Functionalization Methods
Photoinduced Dehydrogenative Borylation via Dihydrogen Bond Bridged Electron Donor and Acceptor Complexes** | Litcius