Thermosensitive Liposomes Encapsulating Nedaplatin and Picoplatin Demonstrate Enhanced Cytotoxicity against Breast Cancer Cells
Sherif Ashraf Fahmy, Eduard Preis, Alice Abu Dayyih, Mohamed Alawak, Hassan Mohamed El-Said Azzazy, Udo Bakowsky, Tamer Shoeib
Abstract
-SC4-ND-TSL, and P-TSL at 40 °C was approximately twice those observed at 37 °C. This study suggests that TSL is a promising nanoplatform for the temperature-triggered release of platinum-based drugs into cancer cells.
Topics & Concepts
ChemistryIn vitroCytotoxicityPolyethylene glycolLiposomePhosphocholinePaclitaxelNuclear chemistryCancerPhosphatidylcholineBiochemistryMedicinePhospholipidMembraneInternal medicineNanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryDendrimers and Hyperbranched Polymers