<i>PNPLA3</i> and <i>TM6SF2 </i>polymorphisms in Brazilian patients with nonalcoholic fatty liver disease
Quelson Coelho Lisboa, Mateus Jorge Nardelli, Patrícia de Araújo Pereira, Débora Marques de Miranda, Stephanie Nunes Ribeiro, Raíssa Soares Neves da Costa, Camila Azevedo Versiani, Paula Vieira Teixeira Vidigal, Teresa Cristina Abreu Ferrari, Cláudia Alves Couto
Abstract
BACKGROUND: genes are determinants of inter-individual and ethnicity-related differences in hepatic fat content and NAFLD progression. AIM: genotype frequency and their association with NAFLD development and progression in Brazilian patients. METHODS: genotype analysis. RESULTS: = 0.78). The T allele presence was not associated with NAFLD or NASH, and was not associated with histological features. CONCLUSION: genetic variants were not associated with NAFLD susceptibility and progressive histological forms in the population studied, but further studies are required to confirm these findings.