Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
Tatiana S. Netterfield, Gerard J. Ostheimer, Andrea R. Tentner, Brian A. Joughin, Alexandra M. Dakoyannis, Charvi D. Sharma, Peter K. Sorger, Kevin A. Janes, Douglas A. Lauffenburger, Michael B. Yaffe
Topics & Concepts
SenescenceDNA damageCell biologyTopoisomeraseMAPK/ERK pathwayBiologyDNACell growthSignal transductionChemistryBiochemistryCancer therapeutics and mechanismsDNA Repair MechanismsTelomeres, Telomerase, and Senescence