Simple Ether‐Directed Enantioselective C(<i>sp</i><sup>3</sup>)−H Borylation of Cyclopropanes Enabled by Iridium Catalysis
Tian Xie, Lili Chen, Zhenlu Shen, Senmiao Xu
Abstract
Abstract Reported here is an efficient and simple ether‐directed iridium‐catalyzed enantioselective C( sp 3 )−H borylation of cyclopropanes. Various functional groups were well‐tolerated, affording a vast array of chiral cyclopropanes with high enantioselectivities. We also demonstrated that the turnover numbers of the current reaction could be up to 335.
Topics & Concepts
BorylationEnantioselective synthesisIridiumChemistryCatalysisEtherCombinatorial chemistryOrganic chemistryMedicinal chemistryArylAlkylCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsAsymmetric Hydrogenation and Catalysis