Discovery of a potent and subtype-selective TYK2 degrader based on an allosteric TYK2 inhibitor
Jun‐ya Kato, Shigeru Korenaga, Masaru Iwakura
Topics & Concepts
Tyrosine kinase 2Allosteric regulationChemistryJurkat cellsLigand (biochemistry)Tyrosine kinaseKinaseBiochemistryReceptorBiologyGeneticsPlatelet-derived growth factor receptorGrowth factorT cellImmune systemProtein Degradation and InhibitorsCytokine Signaling Pathways and InteractionsMultiple Myeloma Research and Treatments