Auto-Induction of Intestinal First-Pass Effect Related Time-Dependent Pharmacokinetics of Artemisinin Rather than Dihydroartemisinin
Liqing Chai, Rongrong Wang, Yan Wang, Wenju Guo, Ning Li, Hengtong Zuo, Yidan Wang, Danyu Duan, Guolian Ren, Bin Zheng, Ruili Wang, Shuqiu Zhang
Topics & Concepts
DihydroartemisininPharmacokineticsFirst pass effectArtemisininPharmacologyOral administrationBioavailabilityCYP2C9Cytochrome P450First passSmall intestineChemistryMedicineMetabolismInternal medicineImmunologyMalariaPlasmodium falciparumArithmeticMathematicsMalaria Research and ControlPharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms