Aldehydes and ketones influence reactivity and selectivity in nickel-catalysed Suzuki–Miyaura reactions
Alasdair K. Cooper, David K. Leonard, Sonia Bajo, Paul M. Burton, David J. Nelson
Abstract
Aldehydes and ketones can have beneficial or detrimental effects on nickel-catalysed reactions. When present on the aryl halide, excellent site-selectivity can be achieved; when present as additives, they inhibit the reaction.
Topics & Concepts
SelectivityNickelChemistryHalideReactivity (psychology)ArylAryl halideCatalysisOrganic chemistryCombinatorial chemistryPalladiumAlkylPathologyMedicineAlternative medicineCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions