Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome
Robert M. H. Grange, Rohit Sharma, Hardik Shah, Bryn Reinstadler, Olga Goldberger, Marissa K. Cooper, Akito Nakagawa, Yusuke Miyazaki, Allyson G. Hindle, Annabelle Batten, Gregory R. Wojtkiewicz, Grigorij Schleifer, Aranya Bagchi, Eizo Marutani, Rajeev Malhotra, Donald B. Bloch, Fumito Ichinose, Vamsi K. Mootha, Warren M. Zapol
Topics & Concepts
HyperoxiaEndocrinologyInternal medicineHypoxia (environmental)Nicotinamide adenine dinucleotideNeurodegenerationLeigh diseaseMedicineNAD+ kinaseNeuroprotectionChemistryOxygenBiochemistryLungEnzymeMitochondrial DNAGeneOrganic chemistryDiseaseMitochondrial Function and PathologyMetabolism and Genetic DisordersATP Synthase and ATPases Research