Physical stability and dissolution of ketoprofen nanosuspension formulation: Polyvinylpyrrolidone and Tween 80 as stabilizers
T. Ismanelly Hanum, Azizah Nasution, Sumaiyah Sumaiyah, Hakim Bangun
Abstract
This study was conducted to improve the dissolution of ketoprofen in nanosuspensions. Ketoprofen nanosuspensions were prepared by a solvent evaporation method using polyvinylpyrrolidone (PVP) and Tween 80 as stabilizers at varied ratios with ketoprofen. Ethanol was used as a solvent for ketoprofen. Physical stability and dissolution of the produced ketoprofen nanosuspensions and conventional suspension were analyzed and compared. The parameters evaluated for their stability for a three-month period were pH, appearance, odor, color, particle size, zeta potential, polydispersity index (PI), and dissolution compared with ketoprofen suspension. Ketoprofen and PVP ratios of 1:1 and 1:1.5 had nano-scale particle sizes of 78.47±0.61 and 156.9±1.55, respectively. These nanosuspensions had stable pH, appearance, odor, color, particle size, and PI at room temperature. The dissolution rates of ketoprofen nanosuspensions were higher compared to that of ketoprofen conventional suspension. PVP and Tween 80 improved ketoprofen nanosuspension dissolution and was stable at room temperature for three months.