Nybomycin Inhibits both Fluoroquinolone-Sensitive and Fluoroquinolone-Resistant Escherichia coli DNA Gyrase
Dmitrii I. Shiriaev, Alina A. Sofronova, Ekaterina A. Berdnikovich, Dmitrii A. Lukianov, Ekaterina S. Komarova, Valeria I. Marina, Yuliya V. Zakalyukina, Mikhail V. Biryukov, Tinashe P. Maviza, Yan A. Ivanenkov, Петр В. Сергиев, Ilya А. Osterman, Olga А. Dontsova
Abstract
Bacterial type II topoisomerases, DNA gyrase and topoisomerase IV, are targets of many antibiotics, including fluoroquinolones (FQs). Unfortunately, a number of bacterial species easily acquire resistance to FQs by mutations in either DNA gyrase or topoisomerase IV genes.
Topics & Concepts
DNA gyraseTopoisomerase IVBiologyTopoisomeraseMicrobiologyEscherichia coliMutantAntibioticsDNAGeneGeneticsCancer therapeutics and mechanismsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and Efficacy