Discovery of Novel Apigenin–Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer
Huan Long, Xiaolong Hu, Baolin Wang, Quan Wang, Rong Wang, Shumeng Liu, Fei Xiong, Zhenzhou Jiang, Xiao‐Qi Zhang, Wen‐Cai Ye, Hao Wang
Abstract
may serve as a lead compound for chemosensitizers and the (BRCA-1)-deficient cancer therapy.
Topics & Concepts
Poly ADP ribose polymeraseChemistryApigeninPolymerasePiperazineRiboseBiochemistryPharmacologyEnzymeFlavonoidOrganic chemistryBiologyAntioxidantPARP inhibition in cancer therapyToxin Mechanisms and ImmunotoxinsBioactive Compounds and Antitumor Agents