The use of a MITO-Porter to deliver exogenous therapeutic RNA to a mitochondrial disease’s cell with a A1555G mutation in the mitochondrial 12S rRNA gene results in an increase in mitochondrial respiratory activity
Yuma Yamada, Minako Maruyama, Tomoko Kita, Shin‐ichi Usami, Shin‐ichiro Kitajiri, Hideyoshi Harashima
Topics & Concepts
Mitochondrial DNARibosomal RNAMT-RNR1BiologyMitochondrionRNAMolecular biologyPoint mutationMutantGeneMutation16S ribosomal RNATransfectionGeneticsMitochondrial Function and PathologyRNA and protein synthesis mechanismsRNA Interference and Gene Delivery