The discovery of novel imidazo[1,2-<i>a</i>]pyridine derivatives as covalent anticancer agents
Qin Song, Qianer Zhang, Xuejing Fan, Fatmata Kayaat, Ruicheng Lv, Jing Li, Yong Wang
Abstract
Novel imidazo[1,2- a ]pyridine-based covalent inhibitors were synthesized via the scaffold hopping strategy. In vitro bioactivity assessment concluded that I-11 is a potent and selective KRAS G12C inhibitor.
Topics & Concepts
Covalent bondChemistryCombinatorial chemistryScaffoldWarheadPyridineNanotechnologyComputer scienceEngineeringMaterials scienceOrganic chemistryAerospace engineeringDatabaseClick Chemistry and ApplicationsSynthesis and Biological EvaluationSynthesis and Reactivity of Heterocycles