Tuning the ignition of CAR: optimizing the affinity of scFv to improve CAR-T therapy
Yanting Duan, Ruoqi Chen, Yanjie Huang, Xianhui Meng, Jiangqing Chen, Chan Liao, Yongmin Tang, Chun Zhou, Xiaofei Gao, Jie Sun
Topics & Concepts
Chimeric antigen receptorCD19AntigenChemistrySingle-chain variable fragmentRecombinant DNAMolecular biologyComputational biologyBiologyBiochemistryImmunologyImmunotherapyGeneImmune systemCAR-T cell therapy researchNanowire Synthesis and ApplicationsAdvancements in Semiconductor Devices and Circuit Design