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Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels

Xia Yao, Shuai Gao, Jixin Wang, Zhangqiang Li, Jian Huang, Yan Wang, Zhifei Wang, Jiaofeng Chen, Xiao Fan, Weipeng Wang, Xueqin Jin, Xiaojing Pan, Yong Yu, Armando Lagrutta, Nieng Yan

2022Cell23 citationsDOIOpen Access PDF

Topics & Concepts

AmiodaroneSofosbuvirPharmacologyPharmacodynamicsBiologyPharmacokineticsChemistryInternal medicineMedicineBiochemistryGeneAtrial fibrillationGenotypeRibavirinIon channel regulation and functionCardiac electrophysiology and arrhythmiasViral Infections and Immunology Research
Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels | Litcius