Tetralactam macrocycle based indicator displacement assay for colorimetric and fluorometric dual-mode detection of urinary uric acid
Huan Yao, Shi-Yao Li, Hong Zhang, Xin‐Yu Pang, Jiale Lu, Cong Chen, Wei Jiang, Liu‐Pan Yang, Lili Wang
Abstract
An indicator displacement assay for colorimetric and fluorometric dual-mode detection of urinary uric acid (UA) was constructed using a water-soluble naphthalene-based tetralactam macrocycle and the phenoxazine dye, resorufin (RF). The visual detection of UA levels of volunteers was successfully realized using modified paper assays, which could be used for the home monitoring of urinary UA.
Topics & Concepts
PhenoxazineUric acidChemistryColorimetryChromatographyDetection limitNaphthaleneUrinary systemBiochemistryOrganic chemistryMedicinePharmacologyInternal medicinePhenothiazineSulfur Compounds in BiologyMolecular Sensors and Ion DetectionLuminescence and Fluorescent Materials