Long-term electronic cigarette exposure induces cardiovascular dysfunction similar to tobacco cigarettes: role of nicotine and exposure duration
Mohamed Elmahdy, Elsayed M. Mahgoup, Mohamed G. Ewees, Mahmoud S. Eid, Tamer M. Abdelghany, Jay L. Zweíer
Abstract
A chronic mouse exposure model that mimics human e-cigarette vaping and allows comparison with tobacco cigarette smoking was developed and utilized to perform longitudinal studies of alterations in cardiovascular function. E-cigarette exposure led to the onset of cardiovascular disease similar to that with tobacco cigarette smoking. Impaired endothelium-dependent and endothelium-independent vasodilation with increased adrenergic vasoconstriction were observed, paralleling the onset of systemic hypertension and subsequent cardiac hypertrophy. This cardiovascular toxicity was dependent on exposure duration and nicotine dose.
Topics & Concepts
NicotineMedicineVasodilationInternal medicinePhenylephrineEndocrinologyEndotheliumMuscle hypertrophyOxidative stressCardiologyPhysiologyPharmacologyBlood pressureSmoking Behavior and CessationAir Quality and Health ImpactsCardiovascular Disease and Adiposity