Synthesis of Zn(<scp>ii</scp>) coordination complexes, their molecular design and docking with SARS-CoV-2 RBD protein and Omicron spike protein
Simranjeet Singh, Mukesh Choudhary
Abstract
Two Zn( ii ) complexes [Zn(L)(en)]ClO 4 (1) and [Zn(L) 2 ] (2) were synthesized and designed and their molecular docking with the SARS-CoV-2 RBD protein and Omicron spike protein were studied for assessing them as possible therapeutic drug candidates against SARS-CoV-2 and its Omicron variant.
Topics & Concepts
ChemistryDocking (animal)Spike ProteinSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)StereochemistryCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)PathologyDiseaseMedicineNursingComputational Drug Discovery MethodsMetal complexes synthesis and propertiesSynthesis and biological activity