Iridium-catalyzed α-selective deuteration of alcohols
Moeko Itoga, Masako Yamanishi, Taro Udagawa, Ayane Kobayashi, Keiko Maekawa, Yoshiji Takemoto, Hiroshi Naka
Abstract
An α-selective, iridium( iii )-bipyridonate-catalyzed hydrogen isotope exchange of alcohols using D 2 O has been developed for the direct, chemoselective deuteration of primary and secondary alcohols, thereby providing deuterated bioactive molecules.
Topics & Concepts
IridiumCatalysisChemistryCombinatorial chemistryOrganic chemistryChemical Reactions and IsotopesAsymmetric Hydrogenation and CatalysisMuon and positron interactions and applications