A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude
Yagmur U. Doruk, Darya Yarparvar, Yasemin Kübra Akyel, Şeref Gül, Ali Cihan Taşkın, Fatma Nur Yilmaz, İbrahim Barış, Nuri Öztürk, Metin Türkay, Narin Öztürk, Alper Okyar, İbrahim Halil Kavaklı
Abstract
Results from further experiments indicated that CLK8 enhances the amplitude of the cellular circadian rhythm by stabilizing the negative arm of the transcription/translation feedback loop without affecting period length. Our results reveal CLK8 as a tool for further studies of CLOCK's role in circadian rhythm amplitude regulation and as a potential candidate for therapeutic development to manage disorders associated with dampened circadian rhythms.
Topics & Concepts
Circadian rhythmCircadian clockBacterial circadian rhythmsBiologyRegulatorCell biologyOscillating geneTranscription factorNeuroscienceGeneticsGeneCircadian rhythm and melatoninLight effects on plantsSpaceflight effects on biology