SIRT1-mediated deacetylation of NF-κB inhibits the MLCK/MLC2 pathway and the expression of ET-1, thus alleviating the development of coronary artery spasm
Bowen Wu, Mishan Wu, Yü Liu, Meng Lu, Jin‐Dong Guo, Meng Yun-hui, Yuhui Zhou
Abstract
Rat coronary artery spasm models exhibit reduced expression of SIRT1. Overexpression of SIRT1 inhibits contraction and proliferation of VSMCs. SIRT1 inhibits NF-κB through deacetylation to modulate VSMC contraction and proliferation. NF-κB activates the MLCK/MLC2 pathway. NF-κB upregulates ET-1 to modulate VSMC contraction and proliferation.
Topics & Concepts
Contraction (grammar)Myosin light-chain kinaseNF-κBChemistryCell biologyAcetylationInternal medicineEndocrinologySignal transductionCancer researchMedicinePhosphorylationBiologyBiochemistryGeneSirtuins and Resveratrol in MedicineRNA regulation and diseaseCalpain Protease Function and Regulation